Chief, Pediatric Allergy and Immunology Program, Joe DiMaggio Children's Hospital

I am chief of the Division of Pediatric Immunology and Allergy at Joe DiMaggio Children’s Hospital. I treat patients with asthma, atopic dermatitis, immune deficiencies and many other conditions.

I love working closely with my patients to manage their care and find a solution to what is ailing them. Thanks to new technology and research, we have a plethora of information, studies and evidenced-based medicine to guide physicians as we provide patient care. While these guidelines are helpful, I also believe it is critical to get to know each of my patients as individuals. The human body is complex and we all react to diseases and treatments differently, so I take the time to listen and understand how my patients are feeling and how their health is impacting their daily life. Being able to help my young patients feel better gives me the greatest satisfaction.

In addition to providing patient care, I am also actively involved in the editing of various medical journals and in the education of young physicians. Currently, I am the associate editor for a couple of journals including the Clinical Reviews in Allergy & Immunology. I believe lifelong learning is important, especially in the medical field where new discoveries take place each day. Through teaching, I hope to pass on my love for learning and inspire the next generation of immunologists to continue to ask questions, broaden their horizons and explore the unknown.

I also hold an academic appointment at the University of California, Davis as clinical professor of medicine in the Department of Rheumatology, Allergy and Clinical Immunology and serve as their associate program director for the Allergy and Immunology Fellowship Training Program.

Hospital Affiliations

• Joe DiMaggio Children's Hospital
• Memorial Hospital Miramar
• Memorial Hospital West
• Memorial Regional Hospital

Gender

• Male

Languages

• Mandarin Chinese
• Cantonese yue

Education

Georgetown University, 1989
Georgetown University, 1989
Georgetown University School Of Medicine, 1985

Internships

Children's Hospital Of Los Angeles, 1987, Pediatrics

Residency

Children's Hospital Of Los Angeles, 1989, Pediatrics

Fellowships

University Of California, 1993, Allergy & Immunology

Certifications

American Board of Allergy and Immunology-Allergy & Immunology
American Board of Pediatrics-Pediatrics

Publications

• Shu Y, Hu Q, Long H, Chang C, Lu Q, Xiao R. Epigenetic variability of CD4+CD25+ Tregs contributes to the pathogenesis of autoimmune diseases. Clin Rev Allergy Immunol 2016 Sept 29 (Epub ahead of print).
• Wu H, Huang X, Qui H, Zhao M, Liao W, Yuan S, Xie Y, Dai Y, Chang C, Yoshimura A, Lu Q. High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells. Sci Rep. 2016 Jun 21: 6:28065. Doi: 10.1038/srep28065
• Deng Y, Chang C, Lu Q. The inflammatory response in psoriasis: A comprehensive review. Clin Rev Allergy Immunol 2016 (epub ahead of print)
• Zhou Y, Wu H, Zhao M, Chang C, Lu Q. The Bach family of transcription factors: A comprehensive review. Clin Rev Allergy Immunol 2016 (epub ahead of print)
• Wu H, Zhao M, Yoshimura A, Chang C, Lu Q. Critical link between epigenetics and transcription factors in the induction of autoimmunity: A comprehensive review. Clin Rev Allergy Immunol 2016 (epub ahead of print)
• Anaya JM, Ramirez-Santana C, Salgado-Castaneda I, Chang C, Ansari A, Gershwin ME. Zika virus and neurologic autoimmunity: the putative role of gangliosides. BMC Med. 2016; 14: 49-51
• Chang C, Ortiz K, Ansari A, Gershwin ME. The Zika outbreak of the 21st century. J Autoimmun. 2016; 68: 1-13
• Islam PS, Chang C, Selmi C, Generali E, Huntley A, Teuber S, Gershwin ME. Medical complications of tattoos: A comprehensive review. Clin Rev Allergy Immunol. 2016;, 50: 273-86
• Li D, Guo B, Li D, Chang C, Lu Q. Primary cutaneous CD4+ small-to-medium- sized pleomorphic T cell lymphoma: a rare case report of infant. J Clin Pathol. 2015; 68(10): 855-8
• Jin H, Zhang G, Zhou Y, Chang C, Lu Q. Old lines tell new tales: Blaschko linear lupus erythematosus. Autoimmunity Rev. 2016; 15: 291-306
• Liao W, Long H, Chang C, Lu Q. The eosinophil in health and disease: From bench to bedside and back. Clin Rev Allergy Immunol. 2016; 50: 125-39

       Book Chapters

• Chang C, Greenspan A, Beltran J, Gershwin ME. Osteonecrosis. In Kelley and Firestein’s Textbook of Rheumatology. 10th Edition. Firestein, GS, Budd RC, Gabriel SE, McInnes IB, O’Dell JR (eds). Amsterdam. Elsevier, 2016: pp 1764-87
• Huang X, Wu H, Chang C, Lu Q. The Mechanism of Skin Damage. In Tsokos, GC. Systemic Lupus Erythematosus, Basic, Applied and Clinical Aspects. Amsterdam, Elsevier, 2016: pp 299-306
• Zhang P, Liu Y, Lu Q, Chang C. Future Challenges and Prospects for Personalized Epigenetics. In Tollefsbol T. Personalized Epigenetics. Amsterdam, Elsevier, 2015: pp 553-71

       Books

• Chang CC, Incaudo GA, Gershwin ME, eds. Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment. Second Edition. New York. Springer, 2014
• Lu Q, Chang C, Richardson, B, eds. Epigenetics and Dermatology. Amsterdam, Elsevier, 2015 

Research

My research interests include, but are not limited to, food allergies, autoinflammatory disease, neonatal lupus and epigenetics, which is the study of changes in gene expression.

Below is a small sampling of my research projects:

• Seafood Allergy research, UCDMC
• Principal Investigator for LAAST/MICT asthma study
• Strive JIA registry
• Food allergy research, Nemours bioresearch
• Principal Investigator for atopic dermatitis research, Nemours Bioresearch
• Principal Investigator for immunoglobulin research study, Nemours Bioresearch
• Principal Investigator for immunodeficiency in CF patients, Nemours Bioresearch
• Principal Investigator for mold allergy research, Nemours Bioresearch
• Principal Investigator for Pacific Rim allergy trial in collaboration with the University of Hong Kong
• Principal Investigator for UC Davis seafood allergy trial Principal Investigator for UC Davis mold allergy trial
• Principal Investigator for Pacific Coast Allergy Medical Corp (see below)
• Research on Kawasaki Disease in Hong Kong with Dr. Y.L. Lau, Department of Paediatrics, University of Hong Kong
• Allergy research on skin-prick testing and in-vitro allergen specific IgE with Dr. Georges Halpern, visiting Professor, Department of Pathology, University of Hong Kong

Presentations

• February 25th, 2016: Asthma and Allergic rhinitis TEVA sponsored conference, Napa, CA
• March 30th, 2016: Asthma and Allergic rhinitis TEVA sponsored conference, Santa Rosa, CA
• April 7th, 2016: Session moderator The pathogenesis and etiology of autoimmunity 10th International Congress of Autoimmunity, Leipzig, Germany
• April 8th, 2016: The Zika virus and autoimmunity: GBS as a case in point 10th International Congress of Autoimmunity, Leipzig, Germany
• May 24th, 2016: Asthma and Allergic rhinitis TEVA sponsored conference, Sausalito, CA
• August 2nd, 2016: Asthma and Allergic rhinitis TEVA sponsored conference, Napa, CA
• October 11th, 2016: Anaphylaxis Second Xiangya Hospital, Central South University, Changsha, China
• December 5st, 2016: Asthma and Allergic rhinitis TEVA sponsored conference, Ukiah, CA
• July 22nd, 2015: Basic immunology North Bay Allergy and Asthma, Napa, CA
• August 4th, 2015: Food allergy North Bay Allergy and Asthma, Napa, CA
• October 22, 2015: How to write a scientific paper Second Xiangya Hospital, Central South University, Changsha, China

Awards

• Leadership Institute, AAAAI, 2015 & 2016
• Dean’s Certificate, Temple University Fox School of Business, 2014
• Beta Gamma Sigma, Temple University Chapter, 2014
• Golden Key International Honors Society, 2014
• University of California at Davis, AAAAI Volunteer Faculty Award for 15 years of service, 2008
• University of California at Davis, AAAAI Volunteer Faculty Award for 25 years of service, 2018